目的探索抗精神病药物氯丙嗪对HepG2细胞的抑制作用。方法常规培养HepG2细胞,设置不同梯度的氯丙嗪药物浓度,从生长能力、克隆形成能力、迁移和侵袭能力来研究氯丙嗪对HepG2细胞的药理作用。结果不同药物浓度下,HepG2细胞的生长能力、克隆形成能力、迁移和侵袭能力随着药物浓度的增高呈递减趋势。结论氯丙嗪对肝癌HepG2细胞有抑制作用。 Objective To explore the inhibitory effect of antipsychotic drug chlorpromazine on HepG2 cells. Methods HepG2 cells were cultured routinely, and different concentrations of chlorpromazine were set up to study the pharmacological effects of chlorpromazine on HepG2 cells from growth, clonality, migration and invasion. Results The growth, clonality, migration and invasion ability of HepG2 cells decreased with the increase of drug concentration under different drug concentrations. Conclusion Chlorpromazine can inhibit HepG2 cells.