视黄醇结合蛋白4(RBP4)是近年来新发现的脂肪细胞因子,不仅参与了糖脂代谢的紊乱,在肥胖人群中显著升高,而且与代谢综合征及其组分以及脂联素密切相关,并且在内脏脂肪细胞功能紊乱和动脉粥样硬化性血管病变中起着重要的媒介作用。研究发现,RBP4与丙型肝炎病毒和非酒精性脂肪肝病变以及肾脏疾病的终末状态有着密切的关系。此外,RBP4在妊娠糖尿病、多囊卵巢综合征等性激素相关性疾病的发生机制中亦起着不可磨灭的作用。 Retinol binding protein 4 (RBP4) is a newly discovered adipocytokines in recent years, not only involved in the disorder of glycolipid metabolism, significantly increased in obese people, but also with the metabolic syndrome and its components and adiponectin close Related, and plays an important mediating role in visceral adipocyte dysfunction and atherosclerotic vascular disease. The study found that RBP4 and hepatitis C virus and non-alcoholic fatty liver disease and kidney disease is closely related to the terminal state. In addition, RBP4 plays an indelible role in the pathogenesis of gestational diabetes and polycystic ovary syndrome and other hormone-related diseases.