多发性骨髓瘤(multiple myeloma,MM)是一种原发于骨髓浆细胞单克隆异常增生所引起的恶性骨肿瘤,骨髓中恶性浆细胞异常增殖,常引起骨骼损害,骨病是其特征性的临床表现。约50%～60%的初诊MM患者经化疗后病情可以获得缓解,但骨髓瘤骨病却鲜有改善,严重影响MM患者的生存质量。近年 Multiple myeloma (MM) is a malignant bone tumor caused by the abnormal proliferation of monoclonal plasma cells in primary bone marrow. The abnormal proliferation of malignant plasma cells in the bone marrow often causes bone damage. Osteopathy is characteristic Clinical manifestations. About 50% to 60% of newly diagnosed MM patients can be relieved of the disease after chemotherapy, but myeloma bone disease rarely improved, seriously affecting the quality of life of patients with MM. in recent years