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[目的]探讨母亲孕期多环芳烃暴露对新生儿体格发育的影响。[方法]在太原市某医院招募217对孕妇-新生儿,签署知情同意书。收集孕妇产前尿液并-80℃保存待检。利用高效液相色谱法测定尿中多环芳烃代谢物,根据4种多环芳烃代谢物之和的第25、75百分位数(P25,P75),将研究对象分为低、中、高暴露组。测量新生儿出生体重、头围、身长,采用出生体重、头围、身长、张路指数(ZLI)评价新生儿体格发育状况。采用多元线性回归分析母亲孕期多环芳烃暴露与新生儿体格发育的关系。[结果]孕妇产前尿中多环芳烃代谢物之和的M(P25,P75)为0.90(0.67,1.27)mg/mol(以Cr计)。多环芳烃低、中、高暴露组新生儿出生体重分别为(3 526.11±380.59)、(3 386.20±394.79)、(3 254.07±402.04)g,出生头围分别为(34.45±1.60)、(33.54±1.92)、(33.47±1.58)cm,出生身长分别为(51.32±1.90)、(51.01±1.53)、(50.28±1.53)cm,ZLI分别为(1.07±0.08)、(1.07±0.10)、(1.03±0.08)g/cm2。除出生体重、头围在中、高暴露组间,出生身长、ZLI在低、中暴露组间的差异无统计学意义(P>0.05)外,其余暴露组间的各指标水平差异均有统计学意义(P<0.05)。多因素回归分析显示,母尿中多环芳烃代谢物之和与新生儿出生体重、头围、身长、ZLI均呈负相关(b分别为-0.21、-0.13、-0.20、-0.16,均P<0.05)。[结论]母亲孕期多环芳烃暴露与新生儿出生体重、头围、身长、ZLI水平降低有关,可能对新生儿体格发育产生不良影响。
[Objective] To investigate the effect of maternal polycyclic aromatic hydrocarbons (PAHs) exposure during pregnancy on the physical development of neonates. [Method] To recruit 217 pregnant women and newborns in a hospital in Taiyuan and sign the informed consent form. Prenatal urine collected from pregnant women and -80 ℃ to be kept pending. According to the 25th and 75th percentiles (P25, P75) of the sum of the four PAHs metabolites, the subjects were divided into low, medium and high Exposed group. Measurement of newborn birth weight, head circumference, length, birth weight, head circumference, length, Zhang Lu index (ZLI) evaluation of physical fitness in newborns. Relationship between polycyclic aromatic hydrocarbons exposure during pregnancy and physical fitness in newborn with multivariate linear regression analysis. [Results] The M (P25, P75) of the sum of PAHs metabolites in prenatal urine of pregnant women was 0.90 (0.67,1.27) mg / mol (calculated as Cr). The birth weights of polycyclic aromatic hydrocarbons in low, middle and high exposure groups were (3 526.11 ± 380.59), (3 386.20 ± 394.79) and (3 254.07 ± 402.04) g, respectively, and the head circumference was 34.45 ± 1.60 and 33.54 ± 1.92 and 33.47 ± 1.58 cm respectively. The length of birth were (51.32 ± 1.90) and (51.01 ± 1.53) and (50.28 ± 1.53) cm, respectively. The ZLI were (1.07 ± 0.08) and (1.07 ± 0.10) (1.03 ± 0.08) g / cm2. Except for birth weight, head circumference in the middle and high exposure groups, birth length, ZLI in the low and medium exposure groups was no significant difference (P> 0.05), the rest of the indicators between the exposure groups were statistically different Significance (P <0.05). Multivariate regression analysis showed that the sum of PAH metabolites in mother’s urine was negatively correlated with birth weight, head circumference, body length and ZLI (b = -0.21, -0.13, -0.20, -0.16, P <0.05). [Conclusion] The mothers’ PAH exposure during pregnancy is related to the decrease of birth weight, head circumference, body length and ZLI level of newborns, which may have adverse effects on the physical development of newborns.