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目的探讨同型半胱氨酸(HCY)和尿酸(UA)水平与中老年人冠心病的关系。方法将218例患者根据冠脉造影结果分为冠心病组和正常对照组,并根据年龄分为中年冠心病组(61例)和对照组(39例)及老年冠心病组(77例)和对照组(41例),分别采用免疫荧光偏振法和氧化酶法测定血清HCY和UA的水平。结果中年和老年冠心病组血清HCY、UA水平均高于各自对照组,差异均有统计学意义(P<0.01或P<0.05),且中年冠心病组HCY、UA水平均高于老年冠心病组,差异均有统计学意义(P<0.01或P<0.05)。多因素Logistic回归分析显示,HCY、UA是中年冠心病患者的独立危险因素(P<0.01或P<0.05);高血压、糖尿病是老年冠心病患者的独立危险因素(P<0.05)。结论高HCY、高UA是中年人冠心病发生的独立危险因素。
Objective To investigate the relationship between homocysteine (HCY) and uric acid (UA) levels and coronary heart disease in the elderly. Methods According to the results of coronary angiography, 218 patients were divided into coronary heart disease group and normal control group, and divided into middle age coronary heart disease group (61 cases) and control group (39 cases) and elderly coronary heart disease group (77 cases) And control group (41 cases). The levels of serum HCY and UA were measured by immunofluorescence polarization and oxidase method respectively. Results The levels of serum HCY and UA in middle-aged and elderly patients with coronary heart disease were significantly higher than those in the control group (P <0.01 or P <0.05), and the levels of HCY and UA in middle-aged patients with coronary heart disease were higher than those in the elderly Coronary heart disease group, the difference was statistically significant (P <0.01 or P <0.05). Multivariate Logistic regression analysis showed that HCY and UA were independent risk factors for middle-aged coronary artery disease (P <0.01 or P <0.05). Hypertension and diabetes were independent risk factors for elderly patients with coronary heart disease (P <0.05). Conclusion High HCY and high UA are independent risk factors of middle-aged coronary heart disease.