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目的 :探讨米非司酮对大鼠异位子宫内膜作用及超微结构影响。方法:建立WistarII级雌性大鼠子宫内膜异位症模型 ,实验组给予10(A组 ) ,25(B组 ) ,50(C组 )mg/(kg·d)米非司酮灌胃 ,对照组只给等量水灌胃 ,4周后处死动物。取异位结节、在位子宫进行病理学及超微病理学研究 ,取血测定雌激素、孕激素、皮质醇。结果:电镜下腺上皮微绒毛有处脱失而呈扁平状 ,整个细胞呈暗调 ,管腔内可见蛋白质分泌物 ,平滑肌细胞核淡染。血清雌、孕激素水平与对照组差别无统计学意义(P>0.05) ;C组血清皮质醇水平减低 ,与对照组差别有统计学意义(P<0.05) ,A组、B组与对照组相比差别无统计学意义(P>0.05)。结论:非米司酮可明显抑制大鼠异位内膜上皮及腺体 ,间质透明变性 ;影响到异位内膜结构。米非司酮对雌孕激素影响不明显。
Objective: To investigate the effect of mifepristone on ectopic endometrium and ultrastructure in rats. Methods: The endometriosis model of WistarII female rats was established. The experimental group was given 10 (group A), 25 (group B) and 50 (group C) mg / (kg · d) Control group only to the same amount of water gavage, 4 weeks after the animals were sacrificed. Take ectopic nodules, in the uterus for pathological and ultrastructural pathology, blood determination of estrogen, progesterone, cortisol. Results: Under electron microscope, the glandular microvilli were flattened and disappeared, the whole cell was dark tone, and protein secretions and smooth muscle cell nucleus were found in the lumen. Serum estrogen and progesterone levels were not significantly different from those of the control group (P> 0.05). The serum cortisol level of group C was lower than that of the control group (P <0.05) The difference was not statistically significant (P> 0.05). Conclusion: The non-mifepristone can significantly inhibit the ectopic endometrial epithelium and gland, interstitial transparent degeneration; affect the ectopic endometrial structure. Mifepristone has no obvious effect on estrogen and progesterone.