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目的观察替普瑞酮联合洛赛克治疗反流性食管炎的临床疗效。方法 96例患者随机分为两组:在洛赛克和吗丁啉基础上观察组加用替普瑞酮,对照组加用硫糖铝。对比观察临床有效率、胃镜下愈合率、不良反应及1 a复发率。结果临床症状缓解时间和总有效率、镜下总有效率及1 a复发率观察组为(9.25±3.54)d和95.83%,93.75%及8.33%,显著优于对照组的(15.72±5.15)d和81.25%,81.25%及22.92%(P<0.05);两组无严重不良反应发生。结论替普瑞酮联合洛赛克治疗反流性食管炎有更好的近期疗效和较低的复发率。
Objective To observe the clinical efficacy of teprenone plus Losec in the treatment of reflux esophagitis. Methods 96 patients were randomly divided into two groups: on the basis of Losec and domperidone plus teprenone observed in the observation group, the control group with sucralfate. Compare clinical efficiency, healing rate under gastroscopy, adverse reactions and 1-year recurrence rate. Results The total effective rate and recurrence rate of clinical symptoms in the observation group were (9.25 ± 3.54) d and 95.83%, 93.75% and 8.33%, respectively, which were significantly better than those in the control group (15.72 ± 5.15) d and 81.25%, 81.25% and 22.92%, respectively (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Teprenone combined with Losec in the treatment of reflux esophagitis has a better short-term efficacy and lower recurrence rate.