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Immunization with inactivated autoreactive T cells(T cell vaccination) selected from individual’s own T cellrepertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactionsof a variety of related surface molecules(1).It induces regulatory immune responses that closely resemble thein vivo situation where the immune system is challenged by clonal activation and expansion of given T cellpopulations in various autoimmune diseases.T cell vaccination provides a powerful means of eliciting naturalreactions of the immune system in response to clonal expansion of T cells,which can be used as a therapeuticapproach to suppress or eliminate specific pathogenic autoreactive T cells in autoimmune conditions.Clinicaltrials using T cell vaccination to deplete autoreactive T cells in human autoimmune conditions have begun toreveal the pathologic relevance of various autoimmune T cell populations in the disease processes,providing aunique opportunity to test the autoimmune theories in a clinical setting.Cellular & Molecular Immunology.2004;1(5):321-327.
Immunization with inactivated autoreactive T cells (T cell vaccination) selected from individual’s own T cellrepertoire provides a unique in vivo setting for testing immune regulation that is known to involve interactions of a variety of related surface molecules (1) .It induces regulatory immune responses that closely resemble the in vivo situation where the immune system is challenged by clonal activation and expansion of given T cellpopulations in various autoimmune diseases. T cell vaccination provides a powerful means of eliciting natural reactions of the immune system in response to clonal expansion of T cells, which can be used as a therapeuticapproach to suppress or eliminate specific pathogenic autoreactive T cells in autoimmune conditions. Clinical trials using T cell vaccination to deplete autoreactive T cells in human autoimmune conditions have begun toreveal the pathologic relevance of various autoimmune T cell populations in the disease processes, providing aunique opportunity to te st the autoimmune theories in a clinical setting. Cellular & Molecular Immunology. 2004; 1 (5): 321-327.