近几年的一些研究认为,在一些疾病中(如Ⅱ型糖尿病及代谢综合征及系统性红斑狼疮等),一直被誉为“好脂蛋白”的高密度脂蛋白(HDL)不仅血浆水平降低,其结构还会发生改变进而功能逆转,加速了动脉粥样硬化(AS)的发展,提高心血管病的风险。因此,阐明失功能性HDL在疾病状态中致AS的机制将有助于心血管疾病的预防与治疗,本文就功能性和失能性HDL的抗AS作用进行了综述。 Several studies in recent years have argued that high-density lipoprotein (HDL), which has been hailed as “good lipoprotein”, has been shown not only in plasma, but also in some diseases, such as type II diabetes and metabolic syndrome and systemic lupus erythematosus The level of reduction, the structure will change and then function reversed, accelerated the development of atherosclerosis (AS), improve the risk of cardiovascular disease. Thus, elucidation of the mechanism by which loss-of-function HDL contributes to disease in the disease state will contribute to the prevention and treatment of cardiovascular disease. The anti-AS effects of functional and disabling HDLs are reviewed in this article.