目的:比较体内光动力治疗与体外光动力疗法对骨性关节炎治疗效果。方法:随机将20只日本大耳白兔分为四组,分别为:空白对照组,模型对照组,体内光动力治疗组及体外光动力治疗组,每组5只兔。除空白对照组外,其余各组均施以改良Hulth方法建立骨性关节炎动物模型。造模8周后,进行光动力疗法治疗。采用HE染色观察软骨形态结构的变化,酶联免疫吸附法(ELISA法)检测血清中COMP、YKL-40及 Objective: To compare the effects of photodynamic therapy and in vitro photodynamic therapy on osteoarthritis in vivo. Methods: 20 Japanese white rabbits were randomly divided into four groups: blank control group, model control group, in vivo photodynamic therapy group and in vitro photodynamic therapy group, with 5 rabbits in each group. Except the blank control group, all the other groups were given the modified Hulth method to establish the animal model of osteoarthritis. Eight weeks after modeling, photodynamic therapy was performed. The morphological changes of cartilage were observed by HE staining. The levels of COMP, YKL-40 and