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该文研究了用反相高效液相色谱（ＨＰＬＣ）法间接测定火炸药组分及其相关化合物在正辛醇／水系统中分配系数的方法。通过对参比物容量因子ｋ′与其正辛醇／水分配系数Ｋｏｗ关系的测定，计算出待测化合物的ｌｇＫｏｗ，获得了各种火炸药组分的正辛醇／水的分配系数，给出了其ｌｎｋ′与ｌｇＫｏｗ值的线性关系式及回归系数。即其中当流动相组成为甲醇水＝７５２５时的线性方程为ｌｇＫｏｗ＝０．５９５３＋１．２９１３ｌｎｋ′（ｎ＝８，γ＝０．９９４１）。解决了因火炸药组分大多数水溶性差、易燃、易爆等问题给用传统摇瓶法测定带来的困难。
In this paper, a method for the indirect determination of partition coefficients of explosives and their related compounds in n-octanol / water system by reversed-phase high performance liquid chromatography (HPLC) was studied. The partition coefficient of n-octanol / water of various explosives components was obtained by measuring the lgKow of the tested compounds by measuring the relationship between the volume fraction of reference substance k ’and its n-octanol / water partition coefficient Kow The lnk ’and lgKow values ?? of the linear relationship and regression coefficients. That is, the linear equation is lgKow = 0.5953 + 1.2913lnk ’(n = 8, γ = 0.9941) when the composition of mobile phase is methanol water = 7525. Solve the fire and explosives components most of the water-soluble, flammable, explosive and other issues to the traditional shake flask method of determination of the difficulties.