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本研究旨在了解弓状核内的阿片受体在体温调节中的作用。研究使用细胞介素ＩＬ１β做致热源。以自动推进器向ＳＤ雄性大鼠弓状核微量注射１μ１ＩＬ１β。在给药前３０ｍｉｎ分别向弓状核微量注射通常阿片受体拮抗剂纳洛酮（Ｎａｌ）、阿片受体μ、δ和κ各自特异性拮抗剂ＣＴＡＰ、ＮＴＩ和ｎｏｒＢＮＩ做预处理，用生理盐水（Ｓａｌ）做对照。结果表明：ＩＬ１β所致的升体温效应能被Ｎａｌ和ＣＴＡＰ阻断，提示弓状核中的阿片受体（主要是μ受体）参与或介导了ＩＬ１β的致热效应；δ和κ受体特异性拮抗剂阻断ＩＬ１β所致的体温升高效应不明显。提示δ和κ阿片受体参与体温调节的可能性较小。对照ＡＲＨ和ＰＯＡＨ中阿片受体在ＩＬ１β所致发热中的作用可发现：二者作用极为相似，这一结果有力地支持了弓状核是体温调节中枢重要组成部分的观点。
This study aimed to understand the role of opioid receptors in the arcuate nucleus in thermoregulation. Study using IL-1β as a source of heat. To S D male rat arcuate nucleus micro injection 1μ1 IL 1β. 30 min before administration, microinjection of naloxone, a typical opioid receptor antagonist, into the arcuate nucleus, pretreatment with CTAP, NTI and nor-BNI, respectively, Saline (Sal) as a control. The results showed that ascending heat effect induced by IL1β could be blocked by Nal and CTAP, suggesting that opioid receptors (mainly μ receptors) in arcuate nucleus participated in or mediated the pyrogenic effect of IL1β; δ and κ receptor antagonist block IL 1β caused by the body temperature is not obvious. Tip δ and κ opioid receptors involved in the regulation of body temperature is less likely. The role of opioid receptors in ARH and POAH in IL-1β-induced fever was found to be very similar between the two, a finding strongly supporting the view that the arcuate nucleus is an important part of the thermoregulatory center.