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目的：研究细胞周期素Ｄ１与子宫颈鳞癌发生、发展及淋巴结转移的关系。方法：采用免疫组织化学方法检测１００例子宫颈鳞癌石蜡包埋组织中细胞周期素Ｄ１的表达，并以８例正常宫颈、１２例宫颈炎组织作为对照。结果：正常宫颈、宫颈炎及宫颈鳞癌组织中细胞周期素Ｄ１阳性率分别为０％、２５％和４８％，三者差异显著（Ｐ＜０．０５）。随子宫颈鳞癌临床分期和组织学分级升高，细胞周期素Ｄ１表达依次增强，且差异均具有显著性（Ｐ＜０．０５）。有淋巴结转移组细胞周期素Ｄ１的表达为７３．８１％，显著高于无淋巴结转移组２９．３１％（Ｐ＜０．０５）。结论：细胞周期素Ｄ１过度表达与子宫颈鳞癌的发生、发展有关，且与淋巴结转移密切相关。
Objective: To investigate the relationship between cyclin D1 and the occurrence, development and lymph node metastasis of cervical squamous cell carcinoma. Methods: Immunohistochemistry was used to detect the expression of cyclin D1 in paraffin embedded tissues of 100 cases of cervical squamous cell carcinoma. Eight cases of normal cervix and 12 cases of cervicitis were used as controls. Results: The positive rates of cyclin D1 in normal cervix, cervicitis and cervical squamous cell carcinoma were 0%, 25% and 48% respectively (P <0.05). With the clinical stage and histological grade of cervical squamous cell carcinoma, the expressions of cyclin D1 increased in turn, and the differences were significant (P <0.05). The expression of cyclin D1 in lymph node metastasis group was 73.81%, which was significantly higher than that in non-lymph node metastasis group (29.31%, P <0.05). Conclusion: The overexpression of cyclin D1 is associated with the occurrence and development of cervical squamous cell carcinoma and is closely related to lymph node metastasis.