聚2—乙烯基吡啶氮一氧化物(PVNO,国外又简称P204)被推荐用于治疗尘肺,关于其毒性作用,研究者们的意见是相互矛盾的,BecK氏及其同事证明了每周给狗肌肉注射5毫升14％P204溶液,注射15次甚至20次,没有引起肾脏机能改变。Grundmann氏认为,习惯上不测定P204的LD_(50)。Mohn及CoIIet氏报导过聚合物(指pVNO。译者)对肾脏的毒性作用,根据A.A.氏及其同事的资料,高分子量—高于500000—的PVNO抑制肺组织和心肌的氧化磷酸化作用,伴有大面积肺脏出血的出血倾向增加,引起实质脏器的营养不良性改变。分析文献上的资料,使我们得出这样的结论,即:必须研究本国生产的PVNO在急性和亚急性 Poly-2-vinylpyridine nitrogen monoxide (PVNO, also referred to as P204 abroad) is recommended for the treatment of pneumoconiosis. The researchers’ opinions contradict each other and Becke’s and his colleagues have proved that weekly Dog muscle injection of 5 ml 14% P204 solution, injection 15 times or even 20 times, did not cause changes in renal function. Grundmann believes that LD_ (50) of P204 is not conventionally measured. Mohn and CoIIet reported the toxic effects of polymers on the kidneys. According to data from AA and colleagues, high molecular weight -> 500000- PVNO inhibited the oxidative phosphorylation of lung and myocardium, Bleeding tendency associated with large areas of lung bleeding increases, causing malnutritional changes in real organs. Analysis of the literature on the literature leads us to the conclusion that it is necessary to study the effects of domestic production of PVNO on acute and subacute