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根性撕脱伤和脊髓损伤是临床上非常重要的疾病,临床治疗方法很多,但难以成功治愈根性撕脱和脊髓损伤引起的瘫痪或慢性疼痛.基因治疗有可能为有效地治疗根性撕脱伤和脊髓损伤,并减轻对病人、家庭、医疗机构和世界经济的影响.癌症的治疗中基因治疗已解决了临床许多挑战性的问题,靶点基因的脊髓损伤研究从实验室走向临床.本综述从臂丛神经撕脱伤和脊髓损伤相关的血脊髓屏障的解剖和病理表现,脊髓损伤和根性撕脱伤基因治疗的种类,以及治疗脊髓损伤活体动物应用到的基因转运载体的种类,重点阐述病毒和非病毒载体转基因治疗在脊髓的转运路径.靶向脊髓的基因治疗已有很长时间,但仍然有问题没有解决,尤其是如何有效地转导病毒载体入在体动物的神经元仍未清楚.在病毒载体的安全性和设计上的问题未解决之前,临床治疗尚需进一步研究.
Radical avulsion and spinal cord injury are clinically very important diseases, many clinical treatment, but it is difficult to successfully cure root avulsion and spinal cord injury paralysis or chronic pain. Gene therapy may be effective for the treatment of root avulsion and Spinal cord injury, and reduce the impact on patients, families, medical institutions and the world economy gene therapy in the treatment of cancer has solved many clinical challenges, the target gene of spinal cord injury research from the laboratory to clinical.This review from Anatomy and pathology of the blood-spinal cord barrier associated with spinal cord injury and avulsion of the brachial plexus, the types of gene therapy for spinal cord injury and root avulsion, and the types of gene delivery vectors used in the treatment of spinal cord injury living animals, highlighting the role of the virus And non-viral vectors in the spinal cord.Transgenic therapy targeting the spinal cord has been around for a long time, but there are still some unsolved problems, especially how to effectively transduce the viral vector into the neurons of the body animal remains unclear Until the safety and design issues of the viral vector are unresolved, further research is needed for clinical treatment.