论文部分内容阅读
目的 探索食管癌肉瘤的组织起源。方法 用免疫组织化学的方法对５例自管癌肉瘤的组织标本进行检测。结果 ５例标本中的癌细胞Ｋｅｒａｔｉｎ均阳性，２例部分癌细胞、３例少数癌细胞Ｖｉｍｅｎｔｉｎ阳性。５例标本的肉瘤成分Ｖｉｍｅｎｔｉｎ均阳性，１例肉瘤成分Ｋｅｒａｔｉｎ阳性。５例标本Ｄｅｓｍｉｎ均阴性。组织学见癌与肉瘤成分有移行，５例中２例发生淋巴结转移，转移的成分１例为癌，１例为肉瘤，并分别为Ｋｅｒａｔｉｎ和Ｖｉｍｅｎｔｉｎ阳性。结论食管癌肉瘤可能起源于食管上皮的未分化储备细胞，部分向上皮分化形成癌，部分向间叶分化形成肉瘤。
Objective To explore the tissue origin of esophageal carcinosarcoma. Methods Five specimens of autologous carcinosarcoma were examined by immunohistochemistry. Results Keratin was positive in all the five specimens. Two of the specimens were cancerous and three of them were positive for Vimentin. Vimentin was positive in 5 specimens of sarcoma, and Keratin was positive in 1 specimen. Desmin was negative in all 5 specimens. In histology, the components of cancer and sarcoma were found to be transitional, and lymph node metastasis occurred in 2 of 5 cases. Metastasis was found in 1 case of cancer and 1 case of sarcoma, and was positive for Keratin and Vimentin, respectively. Conclusion Esophageal carcinoma sarcoma may originate from the undifferentiated reserve cells of the esophageal epithelium, some of which differentiate into epithelial cells to form carcinomas, and some of them differentiate into mesenchymal sarcomas.