7例中度萎缩性鼻炎,先按Young氏法用前庭皮瓣关闭鼻孔,并在数月后再开放时,每侧各取下鼻甲的前或中1/3处活体组织,作扫描电镜观察。结果: 一、萎缩性鼻炎的一般现象:表面无粘液复盖,可观察到从复合小泡腺口渗出的粘液滴互相排斥,并与表面保持分离而不粘着。纤毛稀少、缺如或呈侏儒样,细胞表面短的赘生物样微绒毛明显,与纤毛的发生及成熟的关系不甚清楚。大多数表层细胞变性,柱状细胞纤毛缺失,与基底松离形成成片的粘结面。这些细胞从活细胞到死亡脱落,与游离脓细胞一起,形成痂皮。二、原发性家族性和特发性萎缩性鼻炎之间的比较;除前者有较明显和多数短小纤毛及微绒毛外,所检标本无明显差异。三、鼻关闭的效果:纤毛长度有改进,但数目无变化,呈斑片状分布,不足以推动粘液层。与正常鼻粘膜比较,后者有致密的纤毛及融合的粘液层。 [讨论] 萎缩性鼻炎在光学显微镜下的改 7 cases of moderate atrophic rhinitis, first by Young’s method with the vestibular flap to close the nostrils, and then open a few months later, each side of the nasal turcica removed before or 1/3 of the living tissue for scanning electron microscopy . Results: First, the general phenomenon of atrophic rhinitis: no mucus on the surface covered, can be observed from the composite vesicle exudate sticky mucus droplets mutually exclusive, and with the surface to maintain separation without adhesion. Cilia sparse, absent or was dwarf-like, short cell surface like microvilli nevus, and the occurrence and maturation of cilia is not clear. Most of the superficial cells degenerate and the columnar cilia are missing, leaving the substrate loosely bonded to form a cohesive surface. These cells fall off from living cells to death, together with free pus cells, forming a crust. Second, the primary familial and idiopathic atrophic rhinitis comparison; in addition to the former is more obvious and most short cilia and microvilli, the seized specimens no significant difference. Third, the effect of the nose closure: Cilia length improved, but no change in the number of patchy distribution, not enough to promote the mucus layer. Compared with the normal nasal mucosa, the latter has a dense cilia and mucus layer fusion. [Discussion] Atrophic rhinitis under the optical microscope changes