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药物通过胎盘屏障造成对胎儿影响的问题,Baker 和 Lucey 等曾作过比较全面的综述。近年来一些资本主义国家胎儿畸形的发生率有所增加,(1%以上~7,至少2%~(96))其中药物影响不能除外。因此有关孕妇用药问题引起了学者们的广泛注意,他们从各方面对新药和老药进行了重新审查和评价。本文仅将搜集到的部分资料综述如下:一、药物通过胎盘屏障的几个因素关于药物通过胎盘的机制目前尚未彻底明了,药物在胎盘的转运是否符合非离子扩散的规律也还不清楚。由于研究这一问题所采用的实验操作和动物种类以及所处的妊娠阶段互不相同,因此难以对这些资料进行比较分析。但是可以肯定所有的药物都能以简单的物理扩散或主动转运系统而通过胎盘屏障。兹分述如下:
Drugs through the placental barrier caused by the impact on the fetus, Baker and Lucey had made a more comprehensive review. In recent years, the incidence of fetal malformations has increased in some capitalist countries (more than 1% ~ 7, at least 2% ~ (96)) of which the effects of drugs can not be excluded. Therefore, the issue of medication for pregnant women aroused widespread scholars’ attention. They reviewed and evaluated new and old drugs from all aspects. This article only collects some of the information summarized as follows: First, the drug through the placental barrier Several factors on the mechanism of drug through the placenta is not yet completely clear, drug delivery in the placenta is non-ionic diffusion law is not clear. Due to the fact that the types of experiments and animals used to study this issue are different from each other in the pregnancy stage, it is difficult to compare these data. However, it is certain that all drugs pass the placental barrier with a simple physical diffusion or active transport system. Here are the points: