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目的 探讨谷胱甘肽转移酶π(Glutathione s Transferase π .GST π)与胃癌的分型、分期及预后与多药耐药的关系。方法 应用鼠抗人GST π单克隆抗体对 80例胃癌进行免疫组化研究。结果 GST π表达与临床分期无关 (P>0 .0 5 ) ,与胃癌组织分化程度无关 (P >0 .0 5 )。不同生存年段中GST π的表达无统计学差异 (P >0 .0 5 )。但GST π在癌旁正常组织中的阳性表达与生存期有统计学意义 (P <0 .0 5 )。同时还发现GST π在瘤组织中的表达强度与平均生存期有关 (P <0 .0 5 )。结论 GST π表达与胃癌的分期无关 ,与分型无关 ,不宜作为恶性度的指标 ,但其在瘤组织中的表达强度及在癌旁正常组织中的表达均与生存期有关 ,可做为肿瘤预后的指标
Objective To investigate the relationship between Glutathione s Transferase π (GST π) and the classification, staging and prognosis of gastric cancer and multidrug resistance. Methods 80 cases of gastric cancer were studied by immunohistochemistry using mouse anti-human GST π monoclonal antibody. Results The expression of GST π was not related to the clinical stage (P> 0.05), but not to the degree of gastric cancer (P> 0.05). There was no significant difference in the expression of GST π in different life stages (P> 0.05). However, the positive expression and survival of GST π in adjacent normal tissues were statistically significant (P <0.05). At the same time, it was also found that the expression intensity of GST π in the tumor tissue was related to the mean survival time (P <0.05). Conclusions The expression of GST π is not related to the stage of gastric cancer. It is not related to the typing and should not be used as an indicator of malignancy. However, the expression of GST π in tumor tissue and its expression in normal tissues is related to survival, Prognosis index