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表皮生长因子(Epidermal growth factor,EGF)被提纯已30年,它与多种生理和病理调节有关。EGF是由53个氨基酸组成的单链多肽,分子量6000Da,对热稳定,具有抗胃蛋白酶、胰蛋白酶和糜蛋白酶水解的作用,能促使胃肠粘膜可控性更新生长,保持胃肠道上皮细胞的完整性,抑制胃酸分泌。动物实验证实,EGF能加速半胱氨酸所致十二指肠溃疡(Duodenal Ulcer,DU)的愈合及预防阿斯匹林诱发的消化性溃疡。国内已有报道应用EGF治疗消化性溃疡。为观察EGF对DU的近期疗效,我们自1993年起,应用EGF治疗DU。现将结果报道如下。
Epidermal growth factor (EGF) has been purified for 30 years and is associated with a variety of physiological and pathological conditions. EGF is a single chain polypeptide consisting of 53 amino acids with a molecular weight of 6000 Da. It is thermally stable, has anti-pepsin, trypsin and chymotrypsin hydrolysis effects, and can promote gastrointestinal mucosal controllable renewal and growth, maintain gastrointestinal epithelial cells The integrity of the inhibition of gastric acid secretion. Animal experiments confirmed that EGF can accelerate the healing of cysteine-induced duodenal ulcer (DU) and prevent aspirin-induced peptic ulcer. Domestic application of EGF has been reported in the treatment of peptic ulcer. To observe the recent effect of EGF on DU, we have used EGF to treat DU since 1993. The results are reported below.