目的:探讨胃癌患者手术前后血清糖链抗原199(CA199)、肿瘤特异性生长因子(TSGF)和胃泌素(Gas)含量变化及临床价值。方法:CA199采用酶联免疫法,TSGF采用比色法,Gas采用放射免疫法,对50例胃癌患者手术前后的三项指标的含量进行了检测。结果:胃癌组手术前CA199、TSGF和Gas的含量均明显高于正常对照组(P<0.01),手术后三指标的含量较手术前明显下降(P<0.01)。三指标在胃癌组的阳性检出率分别是:CA199为52%,TSGF为80%,Gas为58%,三指标联合的阳性检出率为92%。结论:胃癌患者血清CA199、TSGF和Gas含量与病情的严重程度相关,三者联合检测可互为补充,提高诊断胃癌的敏感性和准确性,术后联合监测CA199、TSGF和Gas有利于观察病情变化和治疗效果。 Objective: To investigate the changes and clinical value of serum glycogen antigen 199 (CA199), tumor specific growth factor (TSGF) and gastrin (Gas) in patients with gastric cancer before and after operation. Methods: CA199 was detected by enzyme-linked immunosorbent assay (ELISA), colorimetric assay (TSGF) and radioimmunoassay using gas. The contents of three indexes of 50 gastric cancer patients before and after operation were detected. Results: Before operation, the content of CA199, TSGF and Gas in gastric cancer group were significantly higher than those in normal control group (P <0.01). The content of three indexes after operation decreased significantly (P <0.01). The positive rates of three indicators in gastric cancer group were 52% for CA199, 80% for TSGF and 58% for Gas, respectively. The positive detection rate of the three indicators was 92%. CONCLUSIONS: The levels of serum CA199, TSGF and Gas in patients with gastric cancer are correlated with the severity of the disease. The combination of these three tests can complement each other and improve the sensitivity and accuracy of diagnosis of gastric cancer. Combined monitoring of CA199, TSGF and Gas postoperatively is beneficial for the observation of the disease Change and treatment effect.