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迄今,关于使用激素避孕药者能否引起染色体损伤的问题尚有争论。本文作者1979年报导了服用激素和孕激素的复合避孕药的妇女外周血淋巴细胞姐妹染色单体互换频率(SCEs)显著增高,而 H-usum 等(1982)报导使用类似复合避孕药的妇女SCE 频率无如此变化。本文对使用激素避孕药的妇女外周血淋巴细胞 SCEs 作进一步研究及分析。研究对象为20名每天日服复合避孕药(含乙炔雌二醇50μg 或30μg 及 d-18甲基炔诺酮150μg)的妇女,服药周期10～25个月,另有10名妇女每月注射一次含炔诺酮20mg 的孕激素避孕药,连续用药
So far, the question of whether hormonal contraceptives can cause chromosomal damage remains controversial. In 1979, the authors reported a significant increase in the sister chromatid exchange frequency (SCEs) of peripheral blood lymphocytes in women taking combination hormones and progestins, whereas H-usum et al. (1982) reported that women with similar combined contraceptives No such change in SCE frequency. In this paper, the use of hormonal contraceptives in women’s peripheral blood lymphocytes SCEs for further study and analysis. The study population consisted of 20 women who took the combined daily contraceptive (50 μg or 30 μg of ethinyl estradiol and 150 μg of d-18 norgestrel) daily for 10-25 months and another 10 were injected monthly A norethindrone 20mg progestin contraceptives, continuous medication