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目的:探讨放射免疫显像(radioimmunoimaging,RII)在食管癌转移淋巴结定位的临床应用。方法:1.131I标记抗人食管鳞癌单抗G9,形成标记化合物,在胸段食管鳞癌的术前病例,于纤维食管镜下,用纤镜专用注射针,在食管原发灶周围,粘膜下注射131IG9后行RII。2.完成RII后,对清扫淋巴结行放射性测定。结果:1.注药48h时RII在食管旁纵隔、贲门旁、胃小弯旁出现散在的细点状放射性浓集,拟为转移淋巴结所在。2.显像出现散在放射性浓集区域所清扫的淋巴结中,包含有转移淋巴结;无浓集区域,未发现转移淋巴结。3.全部有转移淋巴结的放射性比活度cpm/g均比无转移者高,且均数高出两倍多。结论:用131IG9在食管鳞癌行放射免疫显像,对转移淋巴结有定位作用。
Objective: To investigate the clinical application of radioimmunoimaging (RII) in the localization of metastatic lymph nodes in esophageal cancer. METHODS: 1.131 I was labeled with anti-human esophageal squamous cell carcinoma monoclonal antibody G9 to form labeled compounds in preoperative cases of thoracic esophageal squamous cell carcinoma under fiberoptic esophagoscopy with a dedicated injection needle for the optic nerve around the esophagus primary lesion. RII was injected after 131I-G9 injection. 2. After completion of RII, radioactivity measurements were performed on the dissociated lymph nodes. RESULTS:1. RII appeared scattered fine-spot radioactive concentration in the paramedian paramedian, parapodium, and minor gastric curvature at 48 hours after injection, which was intended to be the location of metastatic lymph nodes. 2. The imaging appeared scattered in the lymph nodes cleared by the radioactive concentration area, including metastatic lymph nodes; no concentrated areas, no metastatic lymph nodes were found. 3. The specific radioactivity of all metastatic lymph nodes was higher than that of non-metastasis, and the average radioactivity was more than two times higher than that of the non-metastasis. Conclusion: Radioimmunoscintigraphy of 131I-G9 in esophageal squamous cell carcinoma has a localization effect on metastatic lymph nodes.