自噬与氧化应激是细胞应激、防御和损伤的重要机制，两者具有密切联系。砷是一种广泛存在于自然环境中的化学污染，国际癌症研究机构(IARC）已经明确砷及其化合物是致癌物质，然而，其致癌机制尚不清楚。近年来的研究发现，自噬与氧化应激在砷致癌过程中发挥重要作用。文中主要对细胞自噬的类型和调控过程、自噬与氧化应激及其与肿瘤发生发展的关系、砷所致的细胞自噬功能改变与氧化应激的关系，两者在砷致癌过程中的作用进行综述。“,”Autophagy and oxidative stress, which are closely related, play important roles in cellular stress response, defense function, and damage. Arsenic is one of the chemical pollutant, which is widely distributed in natural environment. International agency for research on cancer (IARC) has made it clear that arsenic and its compounds are carcinogens. However, the mechanism of carcinogenesis induced by arsenic still remains obscure. Recently, researchers have found that autophagy and oxidative stress play an important role in the process of arsenic carcinogenesis. In this paper, we have reviewed the types and regulation of cellular autophagy, the roles of autophagy and oxidative stress in tumorigenesis, and the effects of arsenic on carcinogenesis.