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以花生凝集素(Peanut agglutinin,简称PNA)为探针,应用ABC免疫组化技术对54例粘液性囊腺瘤、21例交界性粘液性囊腺瘤、12例粘液性囊腺癌的肿瘤细胞进行检测。结果三者的PNA受体阳性率几乎一致(96.3％、100％、100％),提示该受体可能是卵巢粘液性肿瘤的功能分化性标记。阳性强度在++以上者,囊腺癌(33.33％)比囊腺瘤(90.7％)和交界瘤(85.72％)的阳性率均显著降低(P<0.01).PNA标记阳性物的分布形式,囊腺癌以腺腔缘型为主(75％),而囊腺瘤(98.15％)、交界瘤(95.24％)是胞浆型,分布形式差异显著(P<0.01)。表明卵巢粘液性肿瘤在由良性向恶性发展的形态学变化过程中,肿瘤细胞膜表面糖蛋白组成含量发生了变化。
Peanut agglutinin (PNA) was used as a probe to detect the expression of CD44v6 in 54 cases of mucinous cystadenoma, 21 cases of borderline mucinous cystadenoma and 12 cases of mucinous cystadenocarcinoma Test. Results The positive rates of PNA receptors in the three groups were almost the same (96.3%, 100%, 100%), suggesting that the receptor may be a functional differentiation marker of ovarian mucinous tumors. The positive rate of cystadenocarcinoma (33.33%) was significantly lower than that of cystadenoma (90.7%) and borderline tumor (85.72%) (P <0.01) The majority of cystadenocarcinoma was adenohypophysis (75%), while cystadenoma (98.15%) and borderline tumor (95.24%) were cytoplasm with significant difference (P <0.01). That ovarian mucinous tumors in the morphological changes from benign to malignant process, the tumor cell membrane glycoprotein composition changes.