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目的检测2型糖尿病(T2DM)患者外源性血浆凝血因子Ⅶ(FⅦ)、内源性血浆凝血因子Ⅷ(FⅧ)、血浆纤维蛋白原(Fib)、三酰甘油(TG)等指标的水平,探讨其与糖尿病大血管病变(DMAP)的关系,为监测DMAP的发生和将来可能针对此环节实施的预防措施提供必要的理论依据。方法T2DM患者以大血管病变程度进行临床分组:重度DMAP(sDMAP)组、轻度DMAP(mDMAP)组、无DMAP(Non-DMAP)组,并设健康对照组,对4组FⅦ、FⅧ、Fib、TG水平及吸烟人数比例等指标进行比较。结果T2DM患者FⅦ、FⅧ、Fib、TG水平及吸烟人数比例高于健康对照组(P<0.05或<0.01);mDMAP组和sDMAP组高于Non-DMAP组(P<0.01或<0.05);sDMAP组高于mDMAP组(P<0.05)。多因素Logistic回归分析表明FⅦ、FⅧ、Fib和TG、吸烟是DMAP的独立危险因素。结论FⅦ、FⅧ、Fib、TG水平及吸烟人数比例是T2DM及DMAP病变程度的独立危险因素。
Objective To detect the levels of exogenous coagulation factor Ⅶ (FⅦ), endogenous plasma coagulation factor Ⅷ (FⅧ), fibrinogen (Fib) and triglyceride (TG) in type 2 diabetes mellitus To explore its relationship with diabetic macroangiopathy (DMAP) and provide the necessary theoretical basis for monitoring the occurrence of DMAP and possible preventive measures for this aspect in the future. Methods T2DM patients were divided into 4 groups according to their degree of macrovascular disease: severe DMAP (sDMAP), mild DMAP (mDMAP), and no DMAP (non-DMAP) , TG level and the proportion of smoking and other indicators were compared. Results The levels of FⅦ, FⅧ, Fib, TG and the number of smokers in T2DM patients were significantly higher than those in healthy controls (P <0.05 or <0.01); those in mDMAP and sDMAP groups were higher than those in Non-DMAP group (P <0.01 or < Group was higher than mDMAP group (P <0.05). Multivariate logistic regression analysis showed that FⅦ, FⅧ, Fib and TG, smoking were independent risk factors for DMAP. Conclusions FⅦ, FⅧ, Fib, TG levels and the proportion of smokers are independent risk factors for the severity of T2DM and DMAP.