耳硬化症的病因未明。本病有家族性，它以盂德尔见性遗传方式造传，其外显率为25％～40％，在女性和白种人多见，且多为双侧对称性。其它原因有代谢异常，机械或专物刺激等。耳硬化症病灶中有多种灭性细胞，所以病毒感染学说也受重视。最近发现骨吸收和新骨形成是明显的感染性 The etiology of otosclerosis is unknown. The disease is familial, it is described as a genetic method of Mendelian heredity, its penetrance was 25% to 40%, more common in women and Caucasians, and mostly bilateral symmetry. Other reasons are metabolic abnormalities, mechanical or specialized stimuli. Ear sclerosis lesions in a variety of extinction cells, so the virus infection theory is also valued. It has recently been found that bone resorption and new bone formation are clearly infectious