论文部分内容阅读
作者报告46例患者,其中32例(70%)为混合结缔组织疾病(MCTD)、12例(26%)为系统性红斑狼疮(SLE)、药物所致的LE和皮肌炎各1例。女性36例,男性10例,女∶男=3.6∶1。其皮肤症状包括红斑狼疮皮损,手部肿胀或指(趾)端硬化,脱发,血管炎及色素紊乱等。全身症状包括关节炎或关节痛,雷诺氏现象,浆膜炎,血管性头痛,轻度肾病,肌炎和干燥综合征等。实验室检查发现,所有病人正常皮肤直接免疫荧光检查,表皮细胞核都有IgG沉积。43例中35例有抗ENA(可提取的核抗原)抗体(81%),其中30例(86%)有特异性核糖核蛋白(RNP)抗体,他们的临床表现是MCTD。5
The authors reported 46 patients, 32 (70%) with mixed connective tissue disease (MCTD), 12 (26%) with systemic lupus erythematosus (SLE), and 1 drug-induced LE and dermatomyositis. 36 females, 10 males, males: males = 3.6: 1. The skin symptoms include lupus erythematosus, hand swelling or finger-tip sclerosis, hair loss, vasculitis, and pigment disorders. Systemic symptoms include arthritis or joint pain, Raynaud’s phenomenon, serositis, vascular headache, mild kidney disease, myositis and Sjogren’s syndrome. Laboratory tests found that all patients with normal skin direct immunofluorescence, epidermal nuclei have IgG deposition. Of the 43 cases, 35 had anti-ENA antibodies (81%), of which 30 (86%) had specific ribonucleoprotein (RNP) antibodies and their clinical manifestations were MCTD. 5