目的分析手足口病在盐城市的流行病学特征及趋势,为制定相应的防控措施提供科学依据。方法采用描述流行病学方法,对2010—2016年盐城市手足口病疫情进行分析。结果 2010—2016年盐城市累计报告手足口病45 925例,年平均发病率79.64/10万,男性高于女性,差异有统计学意义(χ2=48.011,P<0.01)。4—6月为盐城市手足口病发病高峰,部分年份在10—12月之间出现第2个发病高峰;病例主要集中在经济发达县区,占病例总数的66.84%;发病年龄主要集中在<5岁,占94.71%;确诊病例中EV71型阳性占43.80%,Cox A16型占25.24%,其他肠道病毒占30.96%;共报告重症病例485例,重症率10.56‰,死亡3例,年病死率为0.07‰,重症和死亡病例主要由EV71型病毒株引起。结论盐城市手足口病疫情分布有明显的地区、季节差异,低龄、男性幼童是手足口病高危人群,重症病例多为EV71型病毒感染所致。应在重点季节,对重点人群加强疫情监控与管理,通过积极有效的预防措施实现手足口病发病率的全面降低。 Objective To analyze the epidemiological characteristics and trends of hand, foot and mouth disease in Yancheng City and provide a scientific basis for formulating corresponding prevention and control measures. Methods Descriptive epidemiological methods were used to analyze the epidemic situation of HFMD in Yancheng from 2010 to 2016. Results A total of 45 925 hand-foot-mouth disease cases were reported in Yancheng City from 2010 to 2016, with an average annual incidence of 79.64 / 100 000, which was significantly higher in males than in females (χ2 = 48.011, P <0.01). The peak incidence of hand-foot-mouth disease was in Yancheng from April to June, with the second peak in some years between October and December. The cases mainly concentrated in economically developed counties and districts, accounting for 66.84% of the total cases. The age of onset mainly concentrated in <5 years old, accounting for 94.71%. The positive cases of EV71 accounted for 43.80%, the cases of Cox A16 accounted for 25.24% and other enteroviruses accounted for 30.96%. A total of 485 severe cases were reported, the rate of severe cases was 10.56% The case fatality rate was 0.07 ‰. Severe and fatal cases were mainly caused by the EV71 strain. Conclusion The epidemic situation of hand-foot-mouth disease in Yancheng has obvious regional and seasonal differences. Young children are the most risk of hand-foot-mouth disease in young children. Severe cases are mostly caused by EV71 virus infection. In key seasons, epidemic situation monitoring and management should be strengthened for key populations, and overall reduction in the incidence of hand-foot-mouth disease should be achieved through active and effective preventive measures.