Objective: To establish a refined model of intravenous Caerulein-induced edematous pancreatitis in order to study the pathogenesis and therapeutic protocols of the disesase. Methods: Wistar rats were employed. The osmotic pre-filled with Caerulein and saline was implanted into a subctaneous pocket in the left iliac fossa of the animal. Caerulein was then infused via femoral vein to induce pancreatitis. Results: Pathological examination revealed obvious tissue edema of the pancreas in the rat 6 h after Caerulein infusion. The gross appearance of the pancreas exhibited edema with a clear ’gel- like’ fluid separating the pancreatic Iobules. Interstitial edema and marked vacuolization without inflammatory infiltrations in the Caerulein-infused rats were observed with light microscopy. There was no remarkable remarkable changes in the pancer as of rats infused with normal saline. Conclusion: The advantages of using implantable osmotic pump to infuse Caerulein to rats are the facilitation of animal handling, unrestriction of animal movement in cages and reduction in time lost due to accli matization of the rat to new housing conditions. Objective: To establish a refined model of intravenous Caerulein-induced edematous pancreatitis in order to study the pathogenesis and therapeutic protocols of the disasease. Methods: Wistar rats were employed. The osmotic pre-filled with Caerulein and saline was implanted into a subctaneous pocket in the left iliac fossa of the animal. Caerulein was then infused via femoral vein to induce pancreatitis. Results: Pathological examination revealed obvious tissue edema of the pancreas in the rat 6 h after Caerulein infusion. The gross appearance of the pancreas rendered edema with a clear Interstitial edema and marked vacuolization without inflammatory infiltrations in the Caerulein-infused rats were observed with light microscopy. There was no significant remarkable changes in the pancer as of rats infused with normal saline. The advantages of using implantable osmotic pump to infuse Caerulein to rats are the facilitation of animal handling, unrestriction of animal movement in cages and reduction in time lost due to accli matization of the rat to new housing conditions.