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应用FITC标记的长柔毛野豌豆凝集素(VVL)直接荧光示踪法和VVL介导的花环形成法,在正常小鼠脾、肠系膜淋巴结和胸腺中,分别检测到有一定数量的VVL受体阻性细胞(VV~+细胞)。小鼠在移植肿瘤(EAC)后,脾及淋巴结中VV~+细胞明显地逐步减少。但胸腺中VV~+细胞水平,未发现有改变。有证据表明,VV~+细胞中包含一类反抑制T细胞(Tcs),它们在对肿瘤的免疫排斥中据信发挥重要作用。因此,在肿瘤进展中,外周淋巴器官中VV~+细胞水平的降低,提示了抑制和反抑制调节平衡的失常。这可能是导致肿瘤宿主处于抑制优势的低免疫状态的原因之一。
VVL-mediated vascularization was used to detect VVL receptor in spleen, mesenteric lymph node and thymus of normal mice by using FITC-labeled VVL direct fluorescent tracer method and VVL- Resistive cells (VV ~ + cells). After transplanted tumors (EAC) in mice, VV ~ + cells in the spleen and lymph nodes decreased significantly. However, the level of VV ~ + cells in the thymus was not found to change. There is evidence that VV ~ + cells contain a class of anti-suppressor T cells (Tcs) that are believed to play an important role in immune rejection of tumors. Thus, a decrease in the level of VV ~ + cells in peripheral lymphoid organs during tumor progression suggests a dysregulation of suppression and anti-repression regulation. This may be one of the reasons leading to the tumor host being in a predominantly hypoimmune state.