本文报道1例农民在强烈接触除草剂及杀虫剂后发生了迅速进展性抗肾小球基底膜(GBM)肾炎,导致终末期肾功能衰竭,但无肺部受累。患者50岁男性,病前体健。病前1月在田间用杀虫剂carbofuran及除草剂lenacil喷雾后发生头痛、乏力。2周后再次接触杀虫剂hexachlorocyclohexane及除草剂dinoterb acetate,随后全身不适、腹泻、严重头痛及鼻衄。3天后又用另一种除草剂paraquat,而后出现发热、黑色尿,次晨发生肾功 This report reports that 1 case of farmer developed rapidly progressive glomerular basement membrane (GBM) nephritis after intensive exposure to herbicides and insecticides, resulting in end-stage renal failure without pulmonary involvement. 50-year-old male patient, sick before health. Pre-sick January in the field with pesticides carbofuran and herbicide lenacil headache, fatigue. Two weeks later, the insecticide hexachlorocyclohexane and the herbicide dinoterb acetate were exposed again, followed by general malaise, diarrhea, severe headache and epistaxis. 3 days later with another herbicide paraquat, and then fever, black urine, kidney function occurs the next morning