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多孔碳酸钙微球的弱水溶液稳定性和低再矿化速率限制了其在生物医药领域的应用.为了解决该问题,本论文通过“气体扩散-陈化”两步策略制备了具有大孔结构和方解石相的碳酸钙微球材料.该合成策略反应条件温和,同时不需要使用模板剂和晶型导向剂,能够确保微球产物的生物安全性.所制备的碳酸钙微球可以吸附大量的免疫球蛋白IgY,并表现出增强抑制口腔变形链球菌的能力.此外,研究显示该微球可以在水溶液中保持较高的结构稳定性,而在人体体液和唾液环境中快速再矿化并转变成羟基磷灰石结构,对牙本质小管具有较佳的封闭效果,为其用于治疗牙本质过敏症提供了依据.
The weak aqueous solution stability and the low remineralization rate of porous calcium carbonate microspheres limit its application in the field of biomedicine.In order to solve this problem, this paper prepared a new method with the “gas diffusion-aging” Pore structure and calcite phase of calcium carbonate microsphere material.The synthesis strategy mild reaction conditions, without the use of template agents and crystal-oriented agent, to ensure the biological safety of the microsphere products prepared calcium carbonate microspheres can be adsorbed A large number of immunoglobulin IgY, and showed an enhanced ability to inhibit Streptococcus mutans.In addition, studies have shown that the microspheres can maintain high structural stability in aqueous solution, and rapid remineralization in human body fluids and saliva environment And transformed into hydroxyapatite structure, the dentinal tubules have a better sealing effect, which provides a basis for the treatment of dentin hypersensitivity.