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目的评估上海地区结肠癌常用细胞毒药物使用现状和趋势,为临床合理用药提供参考。方法采用回顾性方法分析2008-2010年上海地区119家医院结肠癌常用细胞毒药物的销售数量、金额、用药频度(DDDs)和限定日费用(DDC),进行药物利用分析。结果结肠癌常用化疗药物总体用量呈快速增长,品种使用显示出明显的变化趋势。卡培他滨、奥沙利铂和西妥昔单抗的用量逐年增长,其药品消耗金额年增长率2009年分别为35.18%、15.62%和23.43%,2010年分别为10.33%、4.90%和20.07%;其药品销售数量增长率2009年分别为103.4%、11.12%和23.73%,2010年分别为10.33%、8.20%和17.81%。结论 2008-2010年结肠癌常用细胞毒药物总体用量呈快速增长,品种使用显示出明显的变化趋势。
Objective To evaluate the status and trends of the commonly used cytotoxic drugs for colon cancer in Shanghai and provide a reference for clinical rational drug use. Methods A retrospective analysis was conducted to analyze the sales volume, amount, frequency of DDDs and DDC of commonly used cytotoxic drugs in colon cancer in 119 hospitals in Shanghai from 2008 to 2010 for drug utilization analysis. Results The overall dosage of chemotherapeutic drugs for colon cancer showed a rapid growth, and the use of varieties showed a clear trend of change. The amount of capecitabine, oxaliplatin and cetuximab increased year by year, and the annual growth rates of their consumption of drugs were 35.18%, 15.62% and 23.43% in 2009 and 10.33%, 4.90% and 20.07%. The growth rate of its sales volume of pharmaceutical products was 103.4%, 11.12% and 23.73% respectively in 2009 and 10.33%, 8.20% and 17.81% respectively in 2010. Conclusion The total amount of commonly used cytotoxic drugs for colon cancer increased rapidly from 2008 to 2010, showing obvious trend of change.