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目的:研究乌司他丁(UTI)在脓毒症大鼠模型中对急性认知功能损害的治疗作用。方法:通过对大鼠腹腔注射脂多糖(LPS,8或16 mg/kg)的方法,形成大鼠的脓毒症模型,并通过Morris水迷宫训练测试其空间学习能力。UTI治疗组在大鼠腹腔注射LPS 16 mg/kg后30 min给予UTI,通过Morris水迷宫测试其空间学习能力。结果:腹腔注射高剂量(16 mg/kg)LPS后4 h和7 h,大鼠的空间学习能力明显受损,注射低剂量(8 mg/kg)LPS的大鼠,其空间学习能力没有明显影响;给予低剂量(50 kU/kg)和高剂量(200 kU/kg)的UTI,可以改善LPS引起的急性认知功能损害。结论:结果表明,早期UTI治疗可以改善大鼠的脓毒症性认知功能损害。
AIM: To investigate the therapeutic effect of ulinastatin (UTI) on acute cognitive impairment in a rat model of sepsis. METHODS: Sepsis models of rats were established by intraperitoneal injection of lipopolysaccharide (LPS, 8 or 16 mg / kg) in rats and their spatial learning ability was tested by Morris water maze training. The UTI group was given UTI 30 min after intraperitoneal injection of LPS 16 mg / kg, and its spatial learning ability was tested by Morris water maze. RESULTS: After 4 and 7 hours of intraperitoneal injection of high dose (16 mg / kg) LPS, the spatial learning ability of rats was significantly impaired. The spatial learning ability was not obvious in rats injected with low dose (8 mg / kg) LPS Effects; low-dose (50 kU / kg) and high-dose (200 kU / kg) UTI can improve the LPS-induced acute cognitive impairment. CONCLUSIONS: The results show that early UTI treatment can improve septic cognitive impairment in rats.