富亮氨酸ɑ-2糖蛋白-1(leucine-rich ɑ2-glycoprotein-1, LRG1)作为富含亮氨酸重复序列蛋白家族成员之一，通过转化生长因子-β(transforming growth factor-β，TGF-β)信号通路影响多种疾病，与脑缺血后的血管生成、内皮细胞凋亡和自噬、炎症反应以及血脑屏障破坏关系密切，有望成为缺血性卒中的新型标志物及治疗靶点。然而，目前探讨LRG1与缺血性卒中关系的研究较少，对于其分子机制认识尚不完善，致使对LRG1在缺血性卒中中的作用存在争议。因此，文章就LRG1-TGF-β信号通路与缺血性卒中的研究进展进行综述，期望为缺血性卒中的早期诊断和防治提供新思路。“,”As one of the leucine-rich repeat protein family members, leucine-rich α-2 glycoprotein 1 (LRG1) affects many diseases by transforming growth factor (TGF)-β signaling pathway, and is closely associated with angiogenesis, endothelial cell apoptosis and autophagy, inflammatory reaction and blood-brain barrier damage after cerebral ischemia. It is expected to become a new marker and therapeutic target of ischemic stroke. However, at present, there are few studies on investigating the relationship between LRG1 and ischemic stroke, and the understanding of its molecular mechanism is not yet complete, resulting in controversy about the role of LRG1 in ischemic stroke. Therefore, this article reviews the research progress of LRG1-TGF-β signaling pathway and ischemic stroke, hoping to provide new ideas for the early diagnosis, prevention and treatment of ischemic stroke.