目的 :研究FVal34Leu基因多态性在汉族人群中的分布情况 ,并探讨其与冠心病及心肌梗死的关系。方法 :应用聚合酶链反应 -单链构像多态性技术检测 398例汉族人 (冠心病组 195例 ,对照组 2 0 3例 )的F基因Val34Leu突变基因型。结果 :Val/Val基因型和Val/Leu基因型频率分别为 95 2 %和 4 8% ,未发现Leu/Leu基因型 ,Leu等位基因频率为 2 4 %。冠心病组和对照组间基因型和等位基因频率无显著差异 (P >0 0 5 )。非心肌梗死组Val/Leu基因型和Leu等位基因分布频率显著高于心肌梗死组 (P <0 0 5 )。结论 :中国汉族人群中存在FVal34Leu基因多态性 Objective: To investigate the distribution of FVal34Leu gene polymorphism in Han population and to explore its relationship with coronary heart disease and myocardial infarction. Methods: Polymerase chain reaction - single strand conformation polymorphism was used to detect the Val34Leu mutation in 398 cases of Han nationality (195 cases of coronary heart disease and 203 cases of control group). Results: The frequencies of Val / Val and Val / Leu genotypes were 95 2% and 48%, respectively. Leu / Leu genotype was not found, and Leu allele frequency was 24%. There was no significant difference in genotype and allele frequencies between CHD group and control group (P> 0.05). Val / Leu genotype and Leu allele frequencies in non-myocardial infarction group were significantly higher than those in myocardial infarction group (P <0.05). Conclusion: FVal34Leu gene polymorphism exists in Chinese Han population