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本文采用高效液相法，对盐酸洛美沙星在健康人体内的生物利用度进行了试验研究。１０名男性健康志愿者单剂量口服盐酸洛美沙星胶囊剂各４００ｍｇ，尔后经时采集静脉血，测定血药浓度，得药－时数据，经ＰＫＢＰ－Ｎ１程序处理，得洛美沙星的药动学参数：Ｌａｇｔｉｍｅ０．２５±０．０７５ｈ，Ｔｍａｘ１．３０±０．４５ｈ，Ｃｍａｘ３．２９±０．７９μｇ／ｍｌ，ｔ１／２α１．８１±１．５３ｈ，ｔ１／２β８．８８±０．６９ｈ，ＶＣ８６．７１±３３．７４Ｌ，Ｋ２１０．２６±０．１５，Ｋ１２０．２６４±０．２４，Ｋ１００．１８７±０．０７４。
In this paper, high performance liquid chromatography was used to study the bioavailability of lomefloxacin hydrochloride in healthy volunteers. 10 male healthy volunteers single oral dose of Lomefloxacin capsules 400mg, after which time collection of venous blood, determination of blood drug concentration, drug-hour data, the PKBP-N1 program to give lomefloxacin pharmacokinetics Learning parameters: Lagtime0.25 ± 0.075h, Tmax1.30 ± 0.45h, Cmax3.29 ± 0.79μg / ml, t1 / 2α1.81 ± 1.53h, t1 / 2β8.88 ± 0.69h, VC86 .71 ± 33.74L, K210.26 ± 0.15, K120.264 ± 0.24, K100.187 ± 0.074.