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对广州市110名于8～9月龄完成麻疹基础免疫的1岁健康儿童,给矛默沙东公司生产的麻疹、流行性腮腺炎和风疹活疫苗(M-M-RⅡ)接种,进行血清学效果监测。结果:麻疹ELISA-IgG抗体在接种疫苗1个月后,阳性率由接种前的64.5％上升到100％,抗体几何平均滴度(GMT)由1:44.6上升至1:2165.1;流行性腮腺炎HI抗体免疫前全部阴性,免后1个月阳性率达89％,GMT由零上升至1:14.6;风疹ELISA-IgG抗体阳性率由接种前的9.1％上升至95％,抗体GMT免后为1:471.6。与默沙东公司及上海市报道的基本相符。我们极力主张1岁以上儿童接种M-M-RⅡ,以预防这3种疾病。M-M-RⅡ是控制和消除这三种疾病流行极其有效的疫苗。
A total of 110 healthy 1-year-old children who completed basic measles immunization from 8 to 9 months of age in Guangzhou were vaccinated with measles, mumps and rubella live vaccine (M-M-RⅡ) produced by Spearheads East and monitored for serological effects. Results: The positive rate of measles ELISA-IgG antibody increased from 64.5% before inoculation to 100% 1 month after vaccination, and the geometric mean antibody titer (GMT) increased from 1: 44.6 to 1: 2165.1. Mumps HI antibody was negative before immunization, the positive rate was 89% at 1 month after immunization, and the GMT increased from zero to 1: 14.6. The positive rate of rubella ELISA-IgG antibody increased from 9.1% before inoculation to 95% 1: 471.6. And Merck East and Shanghai reported the basic match. We strongly advocate vaccination of M-M-R II to children over the age of 1 to prevent these three diseases. M-M-RII is an extremely effective vaccine to control and eliminate the spread of these three diseases.