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有关口腔粘膜癌及癌前病变的bcl-2肿瘤蛋白系列表达研究较少,bcl-2肿瘤蛋白在口腔肿瘤进展中的可能作用仍不清楚。为此,作者用抗生蛋白链菌素技术,对口腔轻、中、重度(包括原位癌)不典型增生各25例及鳞癌60例的石蜡包埋组织切片中的bcl-2表达进行研究,bcl-2免疫反应分级在随机选择的400倍显微镜视野下完成,其中阳性细胞>50%为(卅)、阳性细胞占25%~50%为(卄),10%~24%为(+)、5%~9%为(±)、<5%为(-)。
There are few studies on the expression of bcl-2 oncoproteins in oral mucosa and precancerous lesions. The possible role of bcl-2 in oral tumor progression remains unclear. To this end, the authors used streptavidin technology to study the expression of bcl-2 in paraffin-embedded tissue sections of 25 patients with mild, moderate, and severe (including carcinoma in situ) and 60 patients with squamous cell carcinoma The bcl-2 immunoreactivity was graded in a randomly selected 400 × microscope with> 50% positive cells (卅), 25% ~ 50% positive cells (卄), and 10% ~ 24% ), 5% ~ 9% is (±), <5% is (-).