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本文分析了犬急性心肌梗塞前后及再灌注后QTc间期及血浆丙二醛含量的改变。结果表明心肌梗塞后多数犬出现QTc延长及室性心律失常,再灌注后QTc延长更加明显,室性心律失常发生率也明显高于对照组(p<0.05)。血浆丙二醛浓度心肌梗塞前为1.40±0.38n mol/ml,梗塞后为 2.96±0.53n mol/ml,再灌注时达5.07±0.40n mol/ml。相关分析表明血浆丙二醛浓度与QTc间期呈良好正相关(r=0.761,p<0.05)。
This article analyzes changes in QTc interval and plasma MDA levels in dogs before and after acute myocardial infarction and after reperfusion. The results showed that the majority of dogs after myocardial infarction QTc prolongation and ventricular arrhythmia, QTc after reperfusion more prolonged, ventricular arrhythmia incidence was significantly higher than the control group (p <0.05). Plasma malondialdehyde concentrations before myocardial infarction were 1.40 ± 0.38n mol / ml, 2.96 ± 0.53n mol / ml after infarction, and reached 5.07 ± 0.40n mol / ml after reperfusion. Correlation analysis showed a positive correlation between plasma MDA level and QTc interval (r = 0.761, p <0.05).