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目的:制备一种4-氨基吡啶缓释微丸。方法:采用挤出-滚圆法制备4-氨基吡啶微丸,用丙烯酸树脂水分散体对其包衣,并考察微丸的体外释药。结果:制得的4-氨基吡啶缓释微丸圆整度好,大小均匀,在2 h内释药40.6%,剩余药物在随后的10 h内缓慢释放完全。结论:所制得的4-氨基吡啶缓释微丸体外释药缓慢、平稳,其制备工艺简便,易于操作。
Objective: To prepare a 4-aminopyridine sustained-release pellet. METHODS: 4-Aminopyridine pellets were prepared by extrusion-spheronization. The pellets were coated with an aqueous dispersion of acrylic resin and the in vitro release of pellets was investigated. Results: The 4-aminopyridine sustained-release pellets had good roundness and uniform size and released 40.6% within 2 h. The remaining drugs slowly released within 10 h. Conclusion: The 4-aminopyridine sustained-release pellets prepared in vitro release slow, smooth, the preparation process is simple and easy to operate.