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幽门螺旋杆菌(HP)与胃癌的关系是近来流行病学十分关心的问题.作者试图通过对可以接受根治性外科手术的胃癌病人所作的HP血清学检查结果,提示胃癌与HP间的关系.病人与方法 128例原发胃癌病人,其中男性73例,女性55例.术前应用实验室血清抗体测定血清中抗HP抗体(IgG)的滴度.手术方法常规采用R2或R3胃癌根治术,如肿瘤侵犯胃近端,在切除全胃的同时还要切除脾脏及部分胰腺.手术死亡率为1.6%.根据手术后病理检查结果进行TNM分期,再依据Lauren分类法将组织类型分为弥漫型和肠型,冰冻组织DNA倍体检查.结果 128例中血清检查结果为阳性者82例(64%),阴性者46例(36%).对以上两组进行比较,阳性组中的52例(63%)病变位于胃远端的1/3,阴性组为20例(43%),阳性组BorrmannⅠ、Ⅱ型有19例(23%),阴性组为3例(7%).
The relationship between Helicobacter pylori (H. pylori) and gastric cancer is a matter of great concern in recent epidemiology. The authors tried to show the relationship between gastric cancer and HP by the results of HP serological tests on gastric cancer patients who could undergo radical surgery. Methods 128 patients with primary gastric cancer, including 73 males and 55 females, were preoperatively used laboratory serum antibodies to determine the titer of anti-HP antibody (IgG) in the serum. Surgical methods routinely use R2 or R3 radical gastrectomy, such as The tumor invaded the proximal part of the stomach and removed the whole stomach. At the same time, the spleen and part of the pancreas were removed. The operative mortality was 1.6%. TNM staging was performed according to the postoperative pathological examination results, and the tissue type was divided into diffuse types according to Lauren’s classification method. Intestinal and frozen tissue DNA ploidy examinations. Results Among the 128 patients with positive serum samples, 82 (64%) and 46 (36%) were negative. For the above two groups, 52 of the positive groups ( 63%) lesions located in the distal third of the stomach, negative group was 20 cases (43%), positive group Borrmann I, II type 19 cases (23%), negative group was 3 cases (7%).