以对甲酚、多聚甲醛和取代苯胺为原料,利用Mannich反应法和“分步反应法”合成了一系列新型4-甲基-2-芳胺甲基苯酚,实验结果表明除苯环上没有取代基的产物(4a)外,其余产物经Mannich反应合成的产率均高于经“分步法”合成的产率.特别是经Mannich反应合成目标产物,减少了实验步骤、溶剂的使用和废物的排放,从而减少了环境污染,符合绿色化学的要求.用IR,1H NMR,13C NMR等对产物的结构进行了确证. A series of novel 4-methyl-2-arylamine methylphenols were synthesized by the Mannich reaction method and the “stepwise reaction method” using p-cresol, paraformaldehyde and substituted aniline as starting materials. The yield of the other products synthesized by Mannich reaction is higher than the yield of the synthesis by “Step method.” Especially, the synthesis of the target product by the Mannich reaction reduces the number of experimental steps , The use of solvents and the discharge of wastes, thus reducing the environmental pollution and meeting the requirements of green chemistry.The structures of the products were confirmed by IR, 1H NMR and 13C NMR.