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目的 :观察长期不同负荷的游泳运动对SD大鼠血清瘦素 (Leptin)水平及下丘脑Leptin和神经肽Y(NPY)水平的影响 ,为探讨运动控制体重的中枢机制提供依据。方法 :雄性SD大鼠随机分为对照组、4 5分钟游泳组、90分钟游泳组和 15 0分钟游泳组 ,进行 8周不同负荷游泳训练后测定大鼠血清leptin、下丘脑leptin及NPY水平。结果 :(1)与对照组比较各运动组大鼠体脂含量显著降低 ,但各运动组间无显著性差异。 (2 )各运动组大鼠血清leptin水平与对照组相比均无显著性差异 ,各运动组之间亦无显著性差异。 (3)与对照组相比 ,各运动组下丘脑leptin水平均有所升高 ,但均无显著性差异。各运动组间亦未见显著性差异。 (4)运动组大鼠较对照组下丘脑NPY水平均有所提高 ,但均无显著性意义 ,各运动组间亦无显著性差异。结论 :(1) 8周不同负荷游泳运动显著降低了大鼠的体脂含量 ,起到了控制体重的作用。 (2 )运动对健康大鼠肥胖相关蛋白无直接的、独立的影响。
OBJECTIVE: To observe the effects of chronic long-term swimming exercises on serum Leptin levels and hypothalamic Leptin and Neuropeptide Y (NPY) levels in SD rats, and to provide basis for exploring the central mechanism of exercise-induced weight loss. Methods: Male Sprague - Dawley rats were randomly divided into control group, 45 minutes swimming group, 90 minutes swimming group and 150 minutes swimming group. After 8 weeks of different load swimming training, the levels of leptin, hypothalamic leptin and NPY were determined. Results: (1) Compared with the control group, the body fat content of rats in each exercise group decreased significantly, but there was no significant difference among the exercise groups. (2) There was no significant difference in the level of leptin between the exercise groups and the control group, and there was no significant difference between the exercise groups. (3) Compared with the control group, leptin levels in hypothalamus of all exercise groups increased, but there was no significant difference. There was no significant difference between exercise groups. (4) Compared with control group, rats in exercise group had higher level of NPY in hypothalamus, but no significant difference was found between exercise groups. Conclusion: (1) 8 weeks of different load swimming significantly reduced body fat content in rats, played a role in the control of body weight. (2) Exercise had no direct and independent effect on obesity-related protein in healthy rats.