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山莨菪碱是我国首先从茄科植物唐古特莨菪中分离出的一种生物碱, 是改善微循环衰竭的一种特效药物, 特别是在防治蛇伤 D I C或急性肾衰的病例往往收到意想不到的好结果, 另外, 该药在抢救过程中大剂量 500m g/d(是普通剂量10m g 的 50 倍) 使用而未见明显副作用, 因此, 1987 年以来我们常规使用山莨菪碱治疗 (重症者配合抗蛇毒血清) 各种毒蛇咬伤797 例, 均收到明显效果, 认为山莨菪碱是防治蛇伤血液毒引起 D I C 出血、急性肾衰、微循环衰竭、 M S O F的有效药物, 并可减轻神经毒引起的气道分泌物阻塞、提高血氧分压, 减轻缺氧对大脑的损害,竟争保护胆碱能受体、减轻神经毒性、加快自主呼吸恢复的功能。
Anisodamine is an alkaloid isolated from Solanum Solanum Scopinensis in China at first, which is an effective medicine to improve microcirculation failure, especially in the prevention and treatment of snake injury or acute renal failure To the unexpected good results, in addition, the drug in the rescue process at a high dose of 500m g / d (50 times the normal dose of 10m g) to use without obvious side effects, therefore, since 1987, we routinely use the treatment of anisodamine (Severe with anti-snake venom serum) A variety of snake bites 797 cases, both received significant results, that is, anisodamine is a prevention and treatment of snake-wound blood poisoning caused by D IC bleeding, acute renal failure, microcirculation failure, M S O F Effective drugs, and can reduce neurological toxicity caused by obstruction of airway secretions, improve blood oxygen pressure, reduce oxygen damage to the brain, and strive to protect cholinergic receptors, reduce neurotoxicity and speed up the recovery of spontaneous breathing .