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目的：观察芬太尼透皮贴剂治疗重度癌痛的疗效和毒性。方法：对40例重度癌痛患者进行芬太尼多中心临床随机试验，初始剂量为25μg／h或参照吗啡与芬太尼剂量折算表计算，贴膜每3日更换1次。其间根据疼痛情况进行剂量调整，直到患者无痛或基本无痛。结果：疼痛缓解率为100％，其中完全缓解42．5％，明显缓解57．5％。芬太尼个体剂量为25～50μg／h者占77．5％，少数患者需要更高剂量。该药毒性反应轻，偶有头晕、嗜睡、恶心、呕吐、便秘、排尿困难、皮肤瘙痒等。结论：芬太尼治疗重度癌痛疗效显著。
Objective: To observe the efficacy and toxicity of fentanyl transdermal patch in the treatment of severe cancer pain. Methods: Forty patients with severe cancer pain were randomized to receive a multi-center fentanyl randomized trial. The initial dose was 25 μg / h or calculated on the basis of the dose conversion table of morphine and fentanyl. The membrane was changed every 3 days. During the dose adjustment according to the pain, until the patient is painless or almost painless. Results: The pain relief rate was 100%, of which 42.5% was relieved completely and 57.5% obviously relieved. Fentanyl individual dose of 25 ~ 50μg / h accounted for 77.5%, a small number of patients need higher doses. The drug toxicity, occasional dizziness, drowsiness, nausea, vomiting, constipation, dysuria, skin itching and so on. Conclusion: Fentanyl is effective in treating severe cancer pain.