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选用雄性Wistar大鼠65只,随机分组。1)空白对照组:不做任何处置。2)阴性对照组和实验组:根据Fishcer等人的方法,在大鼠上颌第一磨牙牙颈部用3～0丝线龈缘水平进行结扎,28d后诱导形成大鼠牙周炎,牵引其上颌第一磨牙向近中移动。实验组在加力装置去除前1d开始,腹膜下注射辛伐他汀,阴性对照组注射生理盐水,1次/d,分别保持1、3、7、14、21、28d后处死,免疫组化染色配合定量分析方法观察上颌第一磨牙牙根的近远中侧OPG的表达变化。结
Sixty-five male Wistar rats were randomly divided into groups. 1) blank control group: without any treatment. 2) Negative control group and experimental group: According to the method of Fishcer et al., The maxillary first molars were ligated with gingival margins of 3 ~ 0 at the gingival margin and the rats were induced to form periodontitis in 28 days, First molars to move in the near. The experimental group began 1d before the force device was removed, and the rats in the experimental group were injected subcutaneously with simvastatin. The negative control group was injected with normal saline once a day for 1,3,7,14,21 and 28 days, respectively. With the quantitative analysis of maxillary first molar root OPG expression changes in the medial and distal. Knot