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目的探讨脱氢表雄酮(DHEA)预治疗联合拮抗剂方案在卵巢储备功能低下(DOR)患者体外受精-胚胎移植(IVF-ET)中的应用效果。方法采用随机对照研究,对符合DOR的患者103例,通过随机数字表法,分为实验组(56例)和对照组(47例)。研究组患者先用DHEA胶囊(25mg/粒,GNC,美国),1粒、3次/日口服,疗程3个月,再行拮抗剂方案IVF周期,对照组患者拮抗剂方案IVF周期前未使用DHEA辅助治疗。结果研究组DHEA预治疗后卵巢储备功能参数(bFSH、bAMH、bAFC)较治疗前明显好转,差异有统计学意义(P<0.05),研究组在获卵数、受精率、可利用胚胎数均有增加,差异有统计学意义(P<0.05),而周期取消率、临床妊娠率比较差异无统计学意义(P>0.05)。结论 DHEA预治疗联合拮抗剂方案在DOR患者中的应用价值值得推广。
Objective To investigate the effect of dehydroepiandrosterone (DHEA) pretreatment combined with antagonist on in vitro fertilization-embryo transfer (IVF-ET) in patients with ovarian reserve dysfunction (DOR). Methods A randomized controlled study was conducted in 103 patients with DOR and divided into experimental group (56 cases) and control group (47 cases) by random number table method. Patients in the study group were treated with DHEA capsules (25 mg / tablet, GNC, USA) orally once daily for 3 months for 3 months. The IVF cycle was again followed by the antagonist regimen and the control group was not used before the IVF cycle DHEA adjuvant therapy. Results The ovarian reserve parameters (bFSH, bAMH, bAFC) in the study group were significantly improved after pretreatment with DHEA compared with those before treatment (P <0.05). The number of retrieved oocytes, fertilization rate, number of available embryos (P <0.05), but there was no significant difference in the rate of canceration of cycle and clinical pregnancy (P> 0.05). Conclusion The application of DHEA pretreatment combined with antagonist is worthy of promotion in patients with DOR.