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目的:探讨鼻咽癌组织中的环氧化酶-2(COX-2)、潜伏膜蛋白-1(LMP1)的表达情况,同时分析了两者之间的关系。方法:53例鼻咽癌活检标本,8例鼻咽部慢性炎症常规石蜡切片标本作为对照组,用SP免疫组织化学法检测COX-2、LMP1的表达,采用SPSS12.0统计软件对实验数据进行统计。结果:在鼻咽癌组织中,COX-2阳性表达率为71.70%(38/53);LMP1阳性表达率为66.04%(35/53)。COX-2、LMP1的表达在颈部淋巴结转移组中均明显高于无颈部淋巴结转移组(P<0.05),但在年龄、性别、病理类型、临床分期的分组中均差异无统计学意义(均P>0.05)。在鼻咽癌组织中,LMP1和COX-2的表达存在正相关(γ=0.797,P<0.01)。结论:COX-2、LMP1在鼻咽癌组织中均有表达。COX-2、LMP1在鼻咽癌中的表达和鼻咽癌颈淋巴结转移存在显著相关性,但和年龄、性别、病理类型、临床分期无相关性。COX-2和LMP1在鼻咽癌组织中的表达呈正相关。LMP1可能通过多途径上调COX-2的表达,从而促进鼻咽癌颈部淋巴结转移。
Objective: To investigate the expression of cyclooxygenase-2 (COX-2) and latent membrane protein-1 (LMP1) in nasopharyngeal carcinoma and to analyze the relationship between them. Methods: 53 nasopharyngeal carcinoma biopsies and 8 normal paraffin-embedded specimens of chronic inflammation of nasopharynx were used as control group. The expression of COX-2 and LMP1 were detected by SP immunohistochemistry. The experimental data were analyzed by using SPSS12.0 statistical software statistics. Results: In nasopharyngeal carcinoma, the positive expression rate of COX-2 was 71.70% (38/53), and the positive rate of LMP1 expression was 66.04% (35/53). The expression of COX-2 and LMP1 in cervical lymph node metastasis group were significantly higher than those without cervical lymph node metastasis group (P <0.05), but there was no significant difference in age, sex, pathological type, clinical stage (All P> 0.05). There was a positive correlation between LMP1 and COX-2 expression in NPC (γ = 0.797, P <0.01). Conclusion: Both COX-2 and LMP1 are expressed in NPC tissues. The expression of COX-2 and LMP1 in nasopharyngeal carcinoma was significantly correlated with cervical lymph node metastasis of nasopharyngeal carcinoma, but not with age, gender, pathological type and clinical stage. The expression of COX-2 and LMP1 in nasopharyngeal carcinoma was positively correlated. LMP1 may up-regulate the expression of COX-2 through multiple pathways, so as to promote cervical lymph node metastasis of nasopharyngeal carcinoma.